(K) core course – mandatory course, (E) elective course, ΟΡ (old program), BC (new Biological Chemistry program), FEC (new Food and Environmental Chemisty program), MC (new Materials Chemistry program)

CHE 110 Analytical Chemistry Laboratory I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Analytical Chemistry LAB I is a laboratory course focusing on classical methods of chemical analysis. The main goal of the experiments is to introduce students to analytical chemical work and way of thinking, and to provide skills in the qualitative and quantitative analysis of chemical species in laboratory and real samples. The experiments cover following analytical methods: a) wet chemistry techniques of qualitative analysis, b) classical chromatographic techniques (separation of species by paper and thin layer chromatography, and column ion exchange chromatography), c) gravimetry, d) volumetry (acid-base, complexometric, argentometric and redox titrations) and e) the determination of nitrogen by Kjeldahl.

CHE 111 Analytical Chemistry I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
The course covers the following chapters: Introduction, errors and statistical evaluation of analytical data. Errors in chemical analysis. Application of descriptive and inductive methods of statistics to analytical data. Pre-analytical procedures. Classical and modern methods of dissolution and separation. Classical methods of analysis. Chemical equilibrium and analytical chemistry, equilibria in aquatic solutions, activity and pH. Simple and complex protolytes, acid/base titrations indicators and buffer solutions, titration curves, species distribution diagrammes, nonaqueous solutions of protolytes. Complex formation and complexometric titrations, redox reactions and redox titrations, solubility of salts.

CHE 121 Introductory Chemistry (for Chemists) (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Atomic Structure: Hydrogen Atom (the Bohr model, the Schrödinger equation, the principal, azimuthal, magnetic and spin quantum numbers, the atomic orbitals), Polyelectronic Atoms (the Pauli exclusion principle, the Hund's rule, the building – up principle, electronic configuration).

Periodic table: Blocks, Periods and Groups, Periodicity of Physical Properties, Trends in Chemical Properties.

Chemical Bonds and Molecular Structure: Ionic Βonds, Covalent Bonds, Lewis structure, VSEPR theory, Μolecules with multiple bonds, Μetallic bond.

Nomeclature: Rules for Writing and Naming Inorganic and Metal-Organic Compounds According to IUPAC Conventions.

Thermodynamics and Equilibrium: Free Energy, Enthalpy, Entropy, Equilibrium, Stoichiometry, Solution, Chemical Kinetics, Activation Parameters.

Chemical reactions: Acid - Base Theories, Chemical Reactions, Energy, Basicity - Acidity, Nucleophylicity - Electrophylicity, Potential Definition, Redox Reactions.

Applications: Descriptive Chemistry of the Elements, H2SO4, NH3, Industrial Applications, Environment.

CHE 122 Inorganic Chemistry I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Periodic table of the elements, bonds in inorganic compounds, shapes of inorganic compounds, bond polarity, electrical properties of inorganic solids. Crystal structures of metals and simple ionic compounds (NaCl, CsI, CaF2, CdI2). Basic concepts in crystallography. Thermodynamic properties of inorganic ionic materials. Systematic chemistry of the elements of groups IA, IIA, IIIB, IVB and VIIB. Transition metal elements. Theory of the structure of complexes.

CHE 130 Organic Chemistry Laboratory I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Separation-Purification Methods: Extraction (separation of organic compound mixtures), recrystallisation, distillation, thin layer chromatography (TLC), column chromatography. Isolation of Natural Products: Isolation of eugenol from cloves, Isolation of piperine from pepper. Synthetic Chemistry: Synthesis of piperine. Spectroscopic characterization and comparison with piperine isolated from pepper.

CHE 131 Organic Chemistry I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Fundamental concepts (orbitals, hybridization, electronegativity, types of chemical bonds, resonance, Lewis acidity/basicity). Alkanes and cycloalkanes: nomenclature, physical and chemical properties, conformational analysis, 3D-structures, Newman projections. Classes of chemical reactions, reaction mechanisms and energy diagrams. Alkenes: nomenclature, structure, geometric isomerism (Ε/Ζ, cis/trans), stability, carbocation formation, preparation of, chemical properties. Alkynes: nomenclature, structure, preparation of, chemical properties. Introduction to organic synthesis and retrosynthetic analysis. Stereochemistry: enantiomers, diastereomers, meso-compounds, racemic mixtures, Fischer projections, R/S nomenclature. Stereochmistry of addition reaction to alkenes. Alkylhalides: , structure, preparation of, chemical properties. Nucleophilic substitution (SN2, SN1). Elimination reactions (E1,E2). Spectroscopy (mass IR, NMR, UV). Conjugated dienes. Diels-Alder cycloaddition.

CHE 140 ‑Physical Chemistry Laboratory I ( 7 ECTS (BC, FEC, MC)
OP(K), BC(K), FEC(K), MC(K)
Temperature dependence of the viscosity of liquids. Phase diagram, liquification and critical point. Use of molecular dynamics to study the states of matter. Thermochemistry at constant volume and constant pressure. Chemical equilibria of complexes and indicators. Chemical kinetics: a) Study of a chemical reaction using volumetric determination of the product. b) Study of a hydrolysis reaction using spectroscopic determination of the reactant. c) Study of a saponification reaction using conductivity measurements.

CHE 141 Physical Chemistry I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Ideal and real gases. Kinetic theory of gases. Intermolecular forces, elementary theory of the liquid state. Introduction to chemical kinetics. Kinetics and mechanism. Elementary reactions and their orders. Integrated rate laws. Synthetic mechanisms. Internal energy, work and heat. First law of thermodynamics. Thermochemistry. Thermodynamic and microscopic definition of entropy. Second law of thermodynamics, spontaneous processes and thermal cycles. Entropic calculations in physical and chemical processes. Third law of thermodynamics. Combination of the first and second law and free energies.

CHE 210 Analytical Chemistry Laboratory II (7 ECTS)
OP(K), BC(K), FEC(K), MC(K)
In this course, instrumental qualitative and quantitative analysis experiments are performed. These experiments include spectrometric methods (Ultraviolet – Visible Spectrometry, Infrared Spectrometry, Atomic Emission Spectrometry), chromatographic methods (Gas Chromatography, High Performance Liquid Chromatography), and electrochemical methods (potentiometry, conductivity).

CHE 221 Inorganic Chemistry II (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Bonding Models in Inorganic Chemistry: Ionic Bond (Lattice Energy, the Predictive power of thermochemical calculations on ionic compounds), Covalent Bond (Valence Bond Theory, Molecular Orbital Theory), Electronegativity.

The structure and Reactivity of Molecules: The Structure of Molecules, Structure and Hybrization, Experimental Determination of Molecular Structure, Some Simple Reactions of Covalently Bonded Molecules.

Chemical Forces: Intermolecular Distances and Atomic Radii, Types of Chemical Forces, Hydrogen Bonding, Effects of Chemical Forces.

Acid – Base Chemistry: Acid – Base Concepts, Measures of Acid – Base Strength, Hard and Soft Acids and Bases.

Chemistry in Aqueous and Nonaqueous Solvents: Water, Nonaqueous Solvents, Molten Salts, Electrode Potentials and Electromotive Forces.

Inorganic Chains, Rings, Cages and Clusters: Chains, Rings, Cages, Boron Cage Compounds, Metal Clusters.

CHE 230 Organic Chemistry Laboratory II (7 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Risk Evaluation: R/S risk and safety codes; COSHH compliance. Unknown Identification: purification; spectroscopic analysis and identification; Laboratory Techniques: azeotropic distillation use of Dean-Stark apparatus, vacuum distillation; vacuum sublimation; short path distillation; microscale; multi-step synthesis; thin layer chromatography (TLC), spectroscopic analysis NMR, IR and UV. Project Synthesis: searching the literature, chemical abstracts; planning and costing a 3-step synthesis; evaluating and choosing best synthetic route based on cost and safety. Report Writing: journal format; use of word processing and chemical drawing software. Review of the scientific literature on a topic related to organic chemistry.

CHE 231 Organic Chemistry II (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
NMR Spectroscopy, Benzene and Aromaticity, Benzene Chemistry, Alcohols, Thiols, Ethers, Epoxides, Sulfoxides, Carbonyl Chemistry (Aldehydes, Ketones, Carboxylic Acids and their Derivatives), Amines, Arylamines, Phenols, Pericyclic Reactions (Cycloadditions, Electrocyclic Reactions, Sigmatropic Rearrangements).

CHE 241 Quantum Chemistry (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)

• Τhe need for a quantum consideration of matter. The Rutherford Model, Atomic Emission spectrum of Hydrogen, Rydberg formula, Photoelectric effect. The Bohr atomic model. Wave nature of matter, De Broglie wavelength. Heisenberg uncertainty principle. Schrödinger equation.

• Probabilities, expectation values and operators. Postulates of Quantum Mechanics. Quantum particle-in-a-box. Classic harmonic oscillator. Quantum harmonic oscillator. Tunneling effects. Three-dimensional quantum chemical systems. Rigid Rotor. Spherical harmonics, angular momentum, hydrogen atom.

• Complex quantum systems. Helium atom. Electron spin. Pauli exclusion principle, many-electron atoms. Molecules and Born- Oppenheimer approximation. Valence Bond Theory. Molecular Orbital Theory. Bonding and anti-bonding orbitals, homonuclear and heteronuclear diatomic molecules. Polyatomic molecules, hybridisation states.

CHE 242 Physical Chemistry II (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Introduction to chemical thermodynamics. Chemical potential, fugacity and activity of gases, liquids and mixtures. Solutions and mixtures, colligative properties. Thermodynamic and practical equilibrium constants. Phase equilibria of pure substances. Vapor pressure. Phase transitions. Gibbs's phase rule. Vapor-liquid equilibria, distillation, azeotropic mixtures. Electrolyte solutions, ionic strength. Electrolytic conductance. Galvanic cells, standard electrode potentials and Nernst equation. Electrolysis and transference numbers. Unimolecular reactions. Activated complex theory, dynamic potential surfaces and reaction dynamics. Liquid state reactions. Catalytic and enzymatic reactions.

CHE 311 Analytical Chemistry II (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Instrumental Analysis Methods: Classification, Analytical Instrumentation, Characteristics of Methods, Figures of Merit, Signal-to-Noise Ratio, Sources and Elimination Methods of Noise, Signal-to-Noise Enhancement. Atomic Spectroscopy: Atomic Absorption Spectrometry, Atomic Fluorescence Spectrometry, Atomic Emission Spectrometry, Atomic Mass Spectrometry, Atomic X-Ray Spectrometry. Molecular Spectroscopy: Ultraviolet-Visible Molecular Absorption Spectrometry, Molecular Luminescence Spectrometry, Infrared Spectrometry, Raman Spectroscopy, Nuclear Magnetic Resonance Spectroscopy, Molecular Mass Spectrometry. Electroanalytical Methods: Potentiometry, Coulometry, Voltammetry. Separation Methods: Gas Chromatography, High Performance Liquid Chromatography, Capillary Electrophoresis, Capillary Electrochromatography.

CHE 320 Inorganic Chemistry Laboratory (7 ECTS)
OP(K), BC(K), FEC(K), MC(K)

1. Main group chemistry. Synthesis and characterization of chlorotribenzyltin(IV) and tri(propyloxy)borate.

2. Vanadium Chemistry: Oxidation states, complexes, oxo and non oxo vanadium molecules. Synthesis of bis(acetylacetonate)vanadyl(IV) and tris(catecholate)vanadium(IV) dis(triethylammonium)

3. Cobalt Chemistry: Synthesis, structure and kinetic stability. Synthesis of tris(ethylenediamino)cobalt(III) chloride, [(-)Co(en)3]I3.H2O and [(+)Co(en)3]Ι3.H2O

4. Copper Chemistry: Dinuclear metal complexes, bioinorganic chemistry of copper. Synthesis of aqueous copper(II) acetate, cis- and trans- bis(glycinate)(hydrate)copper(II)

5. Nickel Chemistry: Structure of Nickel complexes, electronic states. Synthesis of bis(hydrate)bis(acetylacetonate)nickel(II), H2Salen and [Ni(salen)].

- Characterization of the compounds:

a) 1H, 13C, 119Sn, 11B NMR spectroscopy 1, 3, 5

b) UV-Vis spectroscopy 2, 3, 4, 5

c) ΙR spectroscopy 2, 4, 5

d) Magnetic Measurments 2, 4, 5

e) Cyclic Voltametry 2, 5

f) Polarometry 3

g) Conductivity 3

h) Melting point 1

CHE 321 ‑Inorganic Chemistry III. Bond Theory, Structure and Reactivity of Metal Complexes.
OP(K), BC(K), FEC(K), MC(K)

1. ‑Coordination Chemistry, Bond, Spectroscopy, Magnetism (Bond theories of metal complexes, infra red and visible spectroscopy of metal complexes, magnetic properties of Metal complexes)

2. ‑Structure (Structure and isomerism of metallorganic molecules with coordination number 1-12, enatiomeric complexes, experimental distinction of enantiomers, chelate effect, macrocyclic ligands, selective binding, template synthesis)

3. ‑Reactions, Kinetics and mechanisms (Substitution reactions of square planar compounds and octahedral complexes, effect of crystal field stabilization to the kinetics of metal complexes, acid and base catalysis, fluctional complexes, redox reactions, inner-outer sphere mechanisms, electron transfer, mixed valence compounds, light induced catalytic reactions, applications.

4. ‑Descriptive chemistry of transition metal, lanthanides and actinides (Periodic table, oxidation states-electrochemistry, chemistry of the various oxidation states of the metal ions, chemistry of the heavier transition metals, bonding and structure of lanthanides and actinides, coordination chemistry, visible spectroscopy and magnetic properties of lanthanides and actinides, transuranium elements)

CHE 331 Organic Chemistry III (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Heterocycles: furan, thiophene, pyrrole, pyridine, quinoline, isoquinoline and indole. Organic Free Radical Chemistry: mechanisms; functional group manipulation; C-C bond formation; Alicyclic Chemistry: ring strain; cycloalkanes (3-7) and larger (8-14 membered) rings. Non-Aromatic Heterocycles and Natural Products: small (3 & 4) and medium (5 & 6-membered) rings, steroids, β-lactams, carbohydrates; alkaloids, stereoelectronic, kinetic & thermodynamic control, NGP, phenolic oxidative coupling. B, Si & Sn: hydroboration, silylenolethers, Shapiro reaction, electrophilic substitution with allylic rearrangement, Crotylsilanes, Brook, Sila-Pummerer & Si-Baeyer-Villiger rearrangement, hydrostannylation, Crotylstannanes, Sn-Li exchange. Pd(0/II), Co & Fe: applications in synthesis; C-C bond formation via transmetallation, cyclisation, carbonyl/alkene insertions. Mixed Mechanism Workshop.
CHE 332 Bioorganic Chemistry (6 ECTS) BC(K)
Combinatorial architecture of biooligomers (proteins, nucleic acids, sugars, lipids, terpenes) and principles of biosynthesis. Chemical synthesis of peptides and oligonucleotides on solid support. Combinatorial synthesis of small molecules and high-throughput screening techniques for lead compound discovery. Gene expression and relation to normal and disease-state, regulation of gene expression by
transcription factors and by small molecules. Post-translational modifications of proteins and their roles. Principles of signal transduction, molecular basis of disease (with emphasis on cancer) and interference with drugs and biological probes. Case studies of activators and inhibitors of signal transducing enzymes. Chemical modification of biomolecular structures. Ligation and labeling methods. Recognition of cellular components by natural and artificial receptors, methods for synthetic preparation of receptors and applications. Biological catalysis for chemical reactions: Enzymes, nucleic acids, RNA as catalyst, ribozymes, Diels-Alderases.

CHE 340 ‑Physical Chemistry Laboratory II (7 ECTS (OP) and 6 ECTS (BC, FEC, MC))
OP(K), BC(K), FEC(K), MC(K)
Dissociation constants for weak bases, partitioning equilibria, complex stability constants, vapor-point elevation, freezing-point depression. Vapor-liquid equilibria. Study of a ternary liquid mixture. Physicochemical characterisation and solubility of copper dodecyl sulfate. Solubilisation of pollutants in micelles of surface active substances. Surface tension of solutions and mixtures. Electrochemical measurements with galvanic cells and their applications. Polarography. Transference numbers and electrolysis. Stabilisation of CdS nanoparticles with polyelectrolytes and their optical properties. Atomic spectra with a diffraction spectrograph. Vibration-rotation spectra using IR-spectrometry. Quantum calculations on conjugated systems of π-electrons using Hyperchem. Magnetic properties of inorganic complexes. Light scattering from polymer solutions. Oxidation mechanism of ascorbic acid. Enzymatic hydrolysis of esters. Study of fast reaction kinetics using the stoppedflow method. Photochemical kinetics using flash photolysis.

CHE 341 Physical Chemistry III (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Electromagnetic radiation and interaction with atoms and molecules. Molecular symmetry and group theory. Quantum mechanical description of the rigid rotor. Rotational spectroscopy of diatomic and polyatomic molecules. Selection rules. Quantum mechanical description of the harmonic oscillator. Vibrational spectroscopy of diatomic and polyatomic molecules. Vibrational-rotational spectra. Raman spectroscopy. Electronic spectroscopy: Pauli's exclusion principle and Hund's rules. Franck-Condon principle. Fluorescence. Phosphoresence. Introduction to lasers and applications. Nuclear magnetic resonance spectroscopy (NMR). Electron paramagnetic resonance spectroscopy (ESR).

CHE 401 Chemistry Diploma Thesis I (3 ECTS)
OP(K), BC(K), FEC(K), MC(K)
The Diploma Thesis work is mandatory for the Bachelor degree in Chemistry. In the first part of the diploma thesis work, students begin work on a given subject under the supervision of a faculty member. Emphasis is placed on the bibliography search and mastering methods and techniques in the laboratory. At the end of semester, the student's performance is assessed by the supervisor and is given the grade "satisfactory" or "unsatisfactory". In the latter case, the student must register in the Diploma Thesis for two additional semesters. The final grade for the Diploma Thesis is given after completion of both CHE 401 and CHE 402.

CHE 402 Chemistry Diploma Thesis II (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
The course is a continuation of CHE 401. In this part, students continue to obtain their experimental data, and discuss and present the data in diagrams, figures and tables.

CHE 403 Chemistry Diploma Thesis Writing (3 ECTS)
OP(K), BC(K), FEC(K), MC(K)
The course is a continuation of CHE 402, at the end of which students write a report on their Diploma Thesis work. In addition, students give an oral presentation before an examination committee on their work and must successfully answer questions about their work.

CHE 404 ‑Undergraduate Diploma Thesis in Biological Chemistry I (3 ECTS)
The Diploma Thesis work is mandatory for the Bachelor degree in Biological Chemistry. In the first part of the diploma thesis work students begin working on a given subject under the supervision of a faculty member. Emphasis is placed on scientific literature search and on mastering methods and techniques in the laboratory. At the end of semester the student's performance is assessed by the supervisor and is marked as "satisfactory" or "unsatisfactory".

In the latter case, the student must register in CHE 404 for one additional semester. The final grade for the Diploma Thesis is given after completion of CHE 407.

CHE 405 ‑Undergraduate Diploma Thesis in Food and Environmental Chemistry I (3 ECTS)
The Diploma Thesis work is mandatory for the Bachelor degree in Food and Environmental Chemistry. In the first part of the diploma thesis work, students begin working on a given subject under the supervision of a faculty member. Emphasis is placed on scientific literature search and on mastering methods and techniques in the laboratory. At the end of semester, the student's performance is assessed by the supervisor and is marked as "satisfactory" or "unsatisfactory".

In the latter case, the student must register in CHE 405 for one additional semester. The final grade for the Diploma Thesis is given after completion of CHE 408.

CHE 406 ‑Undergraduate Diploma Thesis in Materials Chemistry I (3 ECTS)
The Diploma Thesis work is mandatory for the Bachelor degree in Materials Chemistry. In the first part of the diploma thesis work, students begin working on a given subject under the supervision of a faculty member. Emphasis is placed on scientific literature search and on mastering methods and techniques in the laboratory. At the end of semester, the student's performance is assessed by the supervisor and is marked as "satisfactory" or "unsatisfactory".

In the latter case, the student must register in CHE 406 for one additional semester. The final grade for the Diploma Thesis is given after completion of CHE 409.

CHE 407 ‑Undergraduate Diploma Thesis in Biological Chemistry II (6 ECTS)
The course is a continuation of CHE 404. In this part, students continue to obtain their experimental data, and discuss and present the data in diagrams, figures and tables. At the end of CHE 407 students write a report on their Diploma Thesis work. In addition, students give an oral presentation of their work before an examination committee and must successfully answer questions about their work.

CHE 408 ‑Undergraduate Diploma Thesis in Food and Environmental Chemistry II (6 ECTS)
The course is a continuation of CHE 405. In this part, students continue to obtain their experimental data, and discuss and present the data in diagrams, figures and tables. At the end of CHE 408 students write a report on their Diploma Thesis work. In addition, students give an oral presentation of their work before an examination committee and must successfully answer questions about their work.

CHE 409 ‑Undergraduate Diploma Thesis in Materials Chemistry II (6 ECTS)
The course is a continuation of CHE 406. In this part, students continue to obtain their experimental data, and discuss and present the data in diagrams, figures and tables. At the end of CHE 409 students write a report on their Diploma Thesis work. In addition, students give an oral presentation of their work before an examination committee and must successfully answer questions about their work.

CHE 410 Food and Environmental Chemistry Laboratory (5 ECTS)
Laboratory experiments focusing on the analysis of food constituents (carbohydrates, lipids, proteins, enzymes, inorganic components, vitamins), on the qualitative and quantitative determination of chemical additives, toxic and dangerous substances in food, on the determination of pollutants in water. Methods: Gas Chromatography, Liquid Chromatography, Mass Spectroscopy, UV-vis spectroscopy, FTIR spectroscopy.

CHE 411 Food Chemistry (6 ECTS)
Introduction. Water: structure and properties, water activity. Carbohydrates: monosaccharides, oligosaccharides, polysaccharides, non-enzymatic browning (Maillard reaction, caramelization). Amino acids, peptides and proteins: structure and properties of proteins, effects of food processing and storage on proteins, major proteins in milk, meat, cereals. Enzymes: enzyme kinetics, enzymatic browning, enzyme reactions and their utilization in food industry. Lipids, fats and oils: classification, physical and chemical properties, lipid peroxidation, hydrogenation and interesterification. Vitamins: Fat soluble and water soluble vitamins. Minerals. Flavor and aroma substances. Colors. Desirable food constituents and food additives: preservatives, antioxidants, emulsifiers, stabilizers. Non-desirable food constituents and food contamination. Novel foods.

CHE 412 Environmental Chemistry (5 ECTS)
The course deals with the face of chemical substances in the environement and the environmental impact of anthopogenic activities. Chapters included are : chemical and elemental cycles. Atmospheric phenomena and related chemical reactions. Aquatic systems and water/wastewater management. Soil chemistry and waste deposition in geological formations. Chemistry and toxicity of toxic metals and xenobiotica. Analysis of environmental samples.

CHE 413 Special Topics in Qualitative and Quantitative Analysis (5 ECTS)
Chromatographic Methods: high performance liquid chromatography (HPLC) and applications, ion chromatography, size exclusion chromatography. Electrophoretic Methods: capillary electrophoresis sensors in chemical analysis: chemical sensors and biosensors, kinetic methods of chemical analysis. Fluoresence Methods: application of fluorescent tracers, thermal methods of analysis.

CHE 414 Metal Ions in Biological Systems, Environment and Health (5 ECTS)
The main purpose of the course is the presentation and description of bioinorganic systems in relation to the structure and activity of inorganic elements in organisms. Specifically, this course examines: a) trace elements in biosystems, b) effect of trace elements concentration in environment and health and c) pharmaceutical chemistry of inorganic compounds.

CHE 415 Bioanalytical Chemistry
OP(E), BC(K), FEC(K)
The main purpose of this course is to describe the basic principles and the applications of instrumental and molecular methods in the study of biomolecules. Emphasis will be placed on the following topics: a) Biomolecules: amino acids, peptides, proteins, nucleic acids. b) Application of liquid chromatography for bioanalysis: ion exchange, affinity and size exclusion chromatography. c)Methods and applications of gel and capillary electrophoresis in biomolecules. d) Enzyme kinetics. e) Mass spectrometry of biomolecules: MALDI-TOF/MS, ESI/MS. f) Techniques and applications of Uv/Vis, IR and Raman spectroscopy in biomolecules. g)Molecular Recognition: bioassays (antibodies, antigens, immunoassays), biosensors, DNA-arrays. h) Nucleic Acids: amplification (polymerase chain reaction) and sequencing. i) Protein sequencing.

CHE 416 Environmental Radiochemistry (6 ECTS)
This course provides basic knowledge about radionuclides and radiation in the human environment. Radiation is related to natural radionuclides or man-made radionuclides produced and liberated from human activities, such as the production of nuclear energy and storage of nuclear waste. The course aims to provide a broad description of the sources and levels of radioactivity and the chemical behaviour and dispersion of radionuclides in the environment. Methods for monitoring radioactivity and radionuclides in the hydrosphere and biosphere will also be described. The potential effects of natural radioactivity on human health will be discussed.

CHE 417 Sources of pollutants and pollutant dispersion in the environment (6 ECTS)
Examination of the properties which determine the behaviour and dispersion of pollutants in the environment. Separation and distribution of pollutants between air and water, distribution of pollutants between organic phases and water, diffusion, adsorption, chemical and biological transformation reactions, and models.

CHE 418 Methods of analysis and quality control of food (6 ECTS)
Detection and quantification of food components (proteins, lipids, carbohydrates, vitamins, additives, minerals, enzymes, moisture, etc) with analytical methods. Chromatography. Electrochemical measurements. Electrophoresis. Spectrometric techniques. Quality and quality control of food. Quality management systems.

CHE 421 Organometallic Chemistry (6 ECTS)
OP(E), MC(K)
General Introduction to Organometallic Chemistry: Definition, Historical Background, Basic Principles, Molecular Orbital Theory and the 18 – Electron Rule, Counting Electrons in Complexes, the Most Important Applications of Organometallic Compounds.

Classification and Reactivity of Organometallic Metal Complexes: Metal Carbonyl Complexes, Carbonyl Hydride Complexes, Nitrosyl Complexes, Dinitrogen Complexes, Metal - Alkyls, - Carbenes, - Carbynes and - Carbides Complexes, Nonaromatic Alkene and Alkyne Complexes, Allyl and Pentadienyl Complexes, Metallocenes, Arene Complexes, Substitution Reactions, Oxidative Addition, Reductive Elimination, Insertion and Elimination.

Catalysis by Organometallic Compounds: Alkene hydrogenation, Tolman Catalytic Loops, Synthesis Gas, Hydroformylation, Monsanto Acetic Acid Process, the Wacker Process, Synthetic Gasoline, Ziegler – Natta Catalysis, Immobilized Homogeneous Catalysts, a Photodehydrogenation Catalyst "Platinum Pop".

CHE 422 Surface Chemistry (6 ECTS)
OP(E), MC(K)
Introduction: goal, definition of a surface, definition of porosity. Adsorption. Solid-liquid and liquid-gas interface. Adsorption isotherms. Sorption. Solid-gas interface. BET theory and its extensions. Characterisation and measurement of porosity. Characterisation methods for solid surfaces: spectroscopy, photoelectronic spectroscopy, thermogravimetric analysis, adsorption methods, diffraction methods. Basic groups of porous materials and their applications.

CHE 423 Bioinorganic Chemistry (6 ECTS)
OP(E), BC(K)
General Information on Bioinorganic Chemistry: Definition, Historical Background, Basic Principles, Biological Ligands for Metal Ions.

The most Important Biological Functions of Metal Ions: Metalloporphyrins and Respiration, Dioxygen Binding, Transport and Utilization, Binding of Dioxygen to Myoglobin, Physiology of Myoglobin and Hemoglobin, Structure and Function of Hemoglobin, Other Biological Dioxygen Carriers, Photosynthesis, Chlorophyll and the Photosynthetic Reaction Center, Water Oxidizing Center, Enzymes, Vitamin B12 and the B12 Coenzymes, Nitrogen Fixation.

The Biochemistry of Iron: Ferredoxins and Rubredoxins, Availability of Iron, Competition for Iron, Selective Binding of Iron, Siderophores, Iron Storage Proteins.

More Functions of Metal Ions in Biological Systems: Trace elements in Biological Systems, Biochemistry of the Nonmetals, Enviromental Chemistry of Metal Ions, Toxicity, Medicinal Chemistry, Chelate Therapy, Antibiotics and Related Compounds.

CHE 430 Biochemistry laboratory (5 ECTS)
Protein purification (methods: centrifugation, liquid chromatography, electrophoresis), protein quantification, study of enzyme kinetics (activity and kinetic measurements, inhibitors).

CHE 431 Biochemistry I (6 ECTS)
OP(K), BC(K), FEC(K), MC(K)
Introduction. Biochemical evolution. Protein structure and function: primary, secondary, tertiary and quaternary structure, protein folding. DNA and RNA: nucleic acid structure and the flow of genetic information. Enzymes: basic concepts and kinetics, the Michaelis-Menten model. Mechanisms of enzymatic catalysis: proteases, carbonic anhydrases, NMP kinases. Myoglobin and hemoglobin. Regulation of enzymes: allosteric regulation, isoenzymes, covalent regulation, proteolytic activation. Carbohydrates. Lipids and cell membranes. Metabolism: basic concepts and design. Glycolysis and gluconeogenesis. The citric acid cycle. Oxidative phosphorylation.

CHE 432 Biochemistry II (6 ECTS)
OP(K), BC(K)
The light reactions of photosynthesis: conversion of light energy to chemical energy, formation of ATP and storage of reducing power. The dark reactions of photosynthesis (Calvin cycle): conversion of CO2 to carbohydrates. The pentose phosphate pathway: formation of NADPH. Synthesis and degradation of glycogen and their coordinate regulation. Protein and amino acid degradation, the urea cycle. Nitrogen fixation, biosynthesis of amino acids and its regulation. Biosynthesis of nucleotides, anticancer drugs. Stucture of DNA and its replication mechanism. RNA transcription and RNA splicing mechanisms. Protein synthesis mechanism.

CHE 433 Organic Photochemistry (5 ECTS)
Qualitative molecular orbital description of electronic states. Absorption and emission of light, Jablonski diagrams. Physical and chemical properties of excited electronic states. Mechanisms for excitation and decay of excited states. Photochemical reactions. Photochemical synthesis of carbenes.

CHE 434 Biochemical and Molecular Techniques (5 ECTS)
An overview of current techniques in biochemistry and molecular biology. The theory as well as concise protocols of various techniques will be described: cloning of DNA in plasmids and bacteriophages, transformation and selection in bacteria, polymerase chain reaction (PCR), realtime PCR, DNA sequencing, genomic DNA preparation, Southern analysis, production of genomic and cDNA libraries, RNA isolation. Northern analysis, RNase protection, in vitro transcription, reverse transcription and RT-PCR, DNA microarrays, protein purification. Western analysis, coimmunoprecipitation, yeast two hybrid system, ribozymes, RNA interference, tissue culture and transfection techniques, gene expression in mammalian cells, reporter assays, cell cycle analysis, growth curves, apoptosis, animal studies. Current research articles will be presented and analysed.

CHE 435 Retrosynthetic Analysis in Organic Chemistry (5 ECTS)
Basic principles; chemoselectivity; regioselectivity; strategy; C-C disconnections; two group disconnections (Diels Alder reactions, 1,3-bifunctional groups, 1,5-bifunctional groups, 1,2-bifunctional groups, 1,4-bifunctional groups); three membered rings; four membered rings; five membered rings; six membered rings.

CHE 436 Introduction to Medicinal Chemistry (6 ECTS)
OP(E), BC(K)
Classification of drugs; protein and nucleic acids structure; drug action at enzymes, receptors, and nucleic acids (DNA/RNA); drug development; pharmacodynamics; quantitative structure-activity relationships (QSAR); antibacterial agents; the peripheral nervous system: cholinergics, anticholinergics, and anticholinesterases; the opium analgesics; rational approach to drug design.

CHE 437 Introduction to Computational Chemistry (6 ECTS)
OP(E), BC(K)
A general overview of computational methods and their applications in the prediction of physicochemical properties of molecules. The lectures are supplemented by laboratory work where students are trained to use a quantum chemical software. The course covers force fields, semi-empirical, DFT and ab initio methods, the most common basis sets and qualitative molecular orbital theory. Problems include the use of quantum chemical software for structural optimisation, IR spectrum prediction and visualisation of eigenvectors, computation of thermochemical properties, 3-D modelling of molecules and visualisation of molecular orbitals. An introduction to qualitative theoretical models for relating experimental data with computed quantities is also provided.

CHE 438 Introduction to Supramolecular Chemistry (6 ECTS)
Definition and Development of Supramolecular Chemistry. Host–Guest Chemistry. Energetics of Supramolecular Complexes: Experimental Methods. Templates and Self-Assembly. Molecular Devices. Fullerenes and Carbon Nanotubes.

CHE 440 Chemical Technology Laboratory (5 ECTS)
OP(K), MC(K)
Analysis of continuous industrial distillation process: Theory - Laboratory exercise. Chemical reactors (batch and continuous stirred tank reactors): Theory - Applications - Laboratory exercise. Desalination process of water: Theory of reverse osmosis - Laboratory exercise.

CHE 441 Chemical Technology (6 ECTS)
OP(K), MC(K)
Mass balances under steady-state and non-steady-state conditions – Applications. Energy balances under steady-state and non-steady-state conditions – Applications of mass and energy balances. Heat transfer under steady-state and non-steady-state conditions – Heat Exchangers. Chemical reactors – Theory/Applications. Fractional distillation – Theory/Applications. Process analysis of sulphuric acid production. Process analysis of cement production.

CHE 443 Polymer Chemistry (5 ECTS)
OP(E), MC(K)
Introduction, nomenclature and uses. Condensation polymerisation. Free-radical polymerisation. Ionic polymerisation. Photolytic, electrolytic and radiation polymerisations. Polymerisation of cyclic organic compounds. Modification reactions of synthetic polymers. Biological polymers and their chemical reactions. Polymers containing inorganic elements. Relationship between macromolecular structure and properties. Electroactive polymers. Biomedical applications of synthetic polymers.

CHE 445 Catalysis (5 ECTS)
OP(E), MC(K)
Concepts and terms describing the catalytic phenomenon and the causes of its origin. Concepts and terms related to the texture and structure of supported metal catalysts. Basic concepts related to the chemical adsorption and desorption processes associated with a solid surface - Temperatureprogrammed desorption techniques. Preparation and characterisation methods of supported catalysts. Environmental catalysis: Modern de-pollution technologies (air and water pollution). Mechanisms of heterogeneous catalytic reactions.

CHE 446 Special Topics in Molecular Spectroscopy (6 ECTS)
BC(K), MC(K)
Raman Spectroscopy: basic theory: origin of Raman spectra, selection rules, depolarisation ratios, symmetry and selection rules, Resonance Raman spectra, calculation of force constants via normal coordinate analysis, band assignments, Experimental setups and considerations, Special techniques of Raman spectroscopy: highpressure Raman spectroscopy, Raman microscopy, surface-enhanced Raman spectroscopy, time-resolved Raman spectroscopy, matrixisolation Raman spectroscopy, 2D correlation Raman spectroscopy, Raman imaging spectrometry, non-linear Raman spectroscopy. Applications of Raman: spectroscopy in various chemical fields, materials, analytical chemistry, biochemistry and medicine, industry, environment.

Courses offered to students of other departments

CHE 021 ‑Introductory Chemistry (for Biologists and Physicists) (6 ECTS)
  1. Chemistry and the other sciences. The scientific method. Material systems, their properties and models. Physical and chemical phenomena.
  2. Chemical composition of matter. Atoms, molecules, compounds, mixtures, solutions. Dalton´s atomic theory. Internal atomic structure. Chemical terminology, isotopes, ions, atomic mass units. The mole. Introduction to the periodic table of the elements. Ionic and molecular compounds. Nomenclature and properties of ionic compounds.
  3. Simple chemical mol-based calculations. Chemical equations and stoichiometry. Limiting reagent, reaction yield.
  4. Aqueous solution of ionic and molecular compounds. Water as a solvent. Solution concentration units. Dilution, mixing, titration. Reaction types in aqueous ionic solutions. Metathesis reactions and precipitations. Acids and bases and their reactions. Redox reaction, oxidation number.
  5. The road to quantum theory. Bohr model of the H atom. Hydrogen atom, atomic orbitals, polyelectronic atoms, electronic configuration, periodic table, atom size, ionization energy, electron affinity, oxidation state, charge.
  6. Chemical Bonds and Molecular Structure. Ionic and covalent bonds, electron coupling, electronegativity, molecular structure, Lewis structures, VSEPR theory, multiple bonds.
  7. Thermodynamics. Internal energy, heat and work. First law. Thermochemistry, reaction enthalpies, formation enthalpies. Intermolecular forces. Solids, liquids, gases and phase diagrams. Solutions, solubilities, colligative properties. Chemical equilibrium and the equilibrium constant, applications to reactions in gases and liquids. Acid-base reaction, pH scale.
  8. Chemical kinetics, reaction rate, order and mechanism. Kinetic equation, Arrhenius equation, activation energy, catalysis and catalysts.
CHE 022 - Introductory Chemistry for Medicine
Scientific context of Chemistry, its relation to the Biological Sciences and Medicine.Physical, chemical and biological
phenomena.Atomic and molecular structure of matter.Basic chemical nomenclature.Stoichiometry, the concept of the mole, simple chemical calculations in chemical reactions.Chemistry in solution, ionic and covalent compounds, water as a solvent, water in biological systems, types of chemical reactions in solution. Concentration scales in solutions, dilution, titration.
Electronic structure of atoms, Bohr model, electronic configuration and the periodic table of the elements.Periodicity of
element properties, simple description of selected elements, elements important in biology and medicine.Chemical bonding, Lewis symbols, ionic and covalent bond, multiple bonds, concepts of hybridization and resonance.Building-up organic molecules from bonding concepts.Electronegativity, bond polarity, molecular polarity, intermolecular forces, h-bonding, hydrophobicity scales,
solubility and interactions of molecules in biological systems.
Energy in molecular systems, thermodynamiclaws, thermochemistry, enthalpy, entropy and free energy of reactions.Phases of
matter, liquids and vapor pressure, osmotic pressure of solutions, osmosis in biology and medicine, chemical equilibrium concepts.Αcids and bases, pH scale.
Organic chemistry, the chemistry of carbon.Simple nomenclature, active groups on biological molecules, isomerism and chirality
and their applications to drugs.Simple organic chemical reactions of major groups, applications to health sciences.Biological macromolecules, their structural, physicochemical and reactivity properties.Elements of analytical chemistry for the detection and quantification of drugs and molecules of biological significance.
CHE 030 ‑Organic Chemistry Lab for Students of Biology (6 ECTS)
Techniques: Melting point. Boiling point. Simple and fractional distillation. Steam distillation for isolating Eugenol from cloves. Recrystallization of benzoic acid and caffeine. Extraction of salicylic acid from aqueous solution and determination of partition coefficient. Separation of mixture components by extraction. Thin-layer chromatography (TLC) – TLC analysis of analgesic drugs. Reaction mechanisms: Reactivity of alkyl halides under SN1 and SN2 conditions. Synthesis: Synthesis α,β-unsaturated ketones with crossed aldol condensation. Nitration of methyl benzoate. Photochemical reduction of benzophenone. Synthesis and bioassay of Sulfanilamide.

CHE 031 Organic Chemistry for Students of Biology (6 ECTS)
Basic concepts: orbitals, hybridization, electronegativity, types of chemical bonding, classification of reagents, reactive intermediates. Hydrocarbons: alkanes, alkenes, alkynes, cycloalkanes, benzene. Αlcohols, ethers, phenols. Nitro compounds, amines, diazonium salts. Aldehydes, ketones, carboxylic acids and their derivatives. Esters of organic and inorganic acids. Hydrogen bonding in organic compounds. Stereochemistry: enantiomers, diastereomers, geometric isomers. Carbohydrates. Amino acids and proteins. Nucleic acids and nucleotides. Lipids. Stereochemistry and mechanisms of enzymatic reactions.